Download Advances in Cancer Research [Vol 107] G. Vande Woude, G. Klein (AP, 2010) WW PDF

TitleAdvances in Cancer Research [Vol 107] G. Vande Woude, G. Klein (AP, 2010) WW
TagsMedical
LanguageEnglish
File Size3.2 MB
Total Pages245
Table of Contents
                            Advances in Cancer Research
Copyright Page
Contents
Contributors
Chapter 1: Breaking Tolerance in a Mouse Model of Multiple Myeloma by Chemoimmunotherapy
	I. Introduction
	II. Increased Tregs in Mouse Models of MM
		A. Changes in Thymus Structure and Composition
		B. Increased Frequency of Treg Development in the Thymus of MM-Bearing Mice
		C. Adoptive Transfer of Thymocytes from 5T2MM-Diseased Mice Affects the Severity of MM Manifestations in 5T2MM-Injected Mice
	III. Treg Depletion by CYC Improves Antitumor Immunity
		A. Effects of a Single Low- and High-Dose CYC on 5T2MM Progression
		B. Cellular Component of the Immune System in MM
		C. CYC Effects on Molecules Essential for the Survival and Function of Tregs
		D. Adoptive Transfer of Tregs Shortly After Administering CYC to 5T2MM-Bearing Mice
		E. The Effect of CYC on NKT Cells and DCs
		F. A
Window of Opportunity
	IV. Optimal Time Schedules of CYC Treatment Affecting MM Progression
		A. The Clinical Effect of a Single Injection Versus Repeated Injections of Low-Dose CYC at Different Time Intervals
		B. Prolonged Maintenance of Treg Depletion
		C. Residual Tumor Cells
	V. Concluding Remarks
	Acknowledgments
	References
Chapter 2: Obesity, Cholesterol, and Clear-Cell Renal Cell Carcinoma (RCC)
	I. Obesity, Cholesterol, and RCC
	II. Mechanistic Factors Linking Obesity and Lipid Deregulation to RCC
		A. The Role of Leptin and Adiponectin
		B. Regulation of Lipid Biosynthesis—Role of SREBPs
		C. The Clear-Cell Phenotype in RCC
		D. VHL—The “Gate-Keeper” Gene in RCC
	III. Hereditary RCC Genes Affecting Lipid and Protein Biosynthetic Pathways
		A. Birt-Hogg-Dube´/Folliculin
		B. TRC8/RNF139
	IV. Concluding Remarks
	References
Chapter 3: Regulatory T Cells in Cancer
	I. Introduction
		A. Discovery and Fall
		B. Renaissance Through Steady Characterization
	II. Regulatory T Cell Subsets
		A. Naturally Occurring CD4+ Regulatory T cells
		B. Induced (Adaptive) CD4+ Regulatory T Cells
		C. Naturally Occurring and Induced CD8+ Regulatory T Cells
	III. Mechanisms Mediating the Suppressive Function
	IV. Regulatory T Cells in Cancer
		A. Regulatory T Cells in Solid Malignancies
		B. Regulatory T Cells in Hematologic Malignancies
		C. Regulatory T Cells as Biomarkers
	V. Accumulation of Regulatory T cells
		A. Compartmental Redistribution
		B. Expansion
		C. De Novo Generation
		D. Preferential Survival
	VI. Antigen Specificity of Tregs in Cancer
	VII. Cancer Vaccines and Regulatory T Cells
	VIII. Targeting Regulatory T Cells in Cancer Therapy
		A. Depletion of Regulatory T Cells
		B. Targeting Function of Regulatory T Cells
		C. Disrupting Intratumoral Homing of Regulatory T Cells
		D. Modulation of Regulatory T Cell Proliferation/Conversion
		E. Targeting the Antioxidative Capacity of Regulatory T Cells
	IX. Concluding Remarks
	Acknowledgments
	References
Chapter 4: Role of EBERs in the Pathogenesis of EBV Infection
	I. Introduction
	II. Structure of EBERs
	III. Transcriptional Regulation and Expression of EBERs
	IV. Localization of EBERs and Their Interaction with Cellular Proteins
	V. Role of EBERs in Oncogenesis
	VI. Modulation of Innate Immune Signaling by EBERs and Its Contribution to EBV-Mediated Pathogenesis
	References
Chapter 5: Androgen Regulation of Gene Expression
	I. Introduction
	II. Novel Androgen-Regulated Genes (ARGs)
		A. Cell Proliferation and Survival
		B. Lipid and Steroid Metabolism
		C. TMPRSS2:ERG Fusions
		D. MicroRNAs
		E. Miscellaneous
	III. Novel Discoveries Pertaining to Androgen Receptor
		A. Modulation of Androgen Receptor Expression
		B. Regulation of Androgen Receptor Activity
	IV. Conclusions
	References
Chapter 6: MYC in Oncogenesis and as a Target for Cancer Therapies
	I. c-MYC, MYCN, and MYCL: Three Versions of a Multifunctional Protein
		A. Expression Patterns of the MYC Family Genes
		B. Several Levels of Regulation
	II. Networking Is Key with Max Acting as the Spider in the Web
		A. Protein Interaction and Downstream Effects
	III. MYC-Mediated Repression
	IV. Induction of Apoptosis
	V. Regulation of Stemness
	VI. Oncogenic Properties
	VII. No Transformation Without MYC?
	VIII. MYC-Associated Cancers and Their Treatment
		A. Breast Cancer
		B. Treatment of Breast Cancer
		C. Burkitt’s Lymphoma (BL)
		D. Treatment of BL
		E. Lung Cancer
		F. Treatment of Lung Cancer
		G. Medulloblastoma
		H. Treatment of Medulloblastoma
		I. Neuroblastoma
		J. Treatment of Neuroblastoma
		K. Rhabdomyosarcoma (RMS)
		L. Treatment of RMS
	IX. Novel Therapies
		A. Rational Design and Synthetic Modeling: Successful Examples
	X. Targeted Therapy: What Is in the Future for MYC?
		A. Substances Interfering with the MYC Pathway
		B. Transient Inactivation of MYC
	XI. Concluding Remarks
	Acknowledgments
	References
Index
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Document Text Contents
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4_GR03.eps


Type I IFNs induced by RIG-I activation

RNA helicase domain

Inflammatory cytokines

CARD

IPS-1

IFNR

PKR
RIG-I

IRF3

Type I IFNs

NF-kB
Nuclei

Cytoplasm

EBV-infected BL cells

Resistance to apoptosis

Autocrine growth of BL

EBER

(mitochondria)

Transcription factors

EBER

IL-10

Fig. 3, Dai Iwakiri and Kenzo Takada (See Page 129 of this volume.)

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4_GR04.eps


EBV-infected lymphocytes

DCs, EBV-infected T or NK cells, etc.

La

TLR3

NF-kB

Activation of innate immunity
Activation of EBV-infected T or NK cells

Hypercytokinemia
Pathogenesis of active EBV infectious diseases

Type I
IFNs

Inflammatory
cytokines

IRF3

TRIF

EBER

EBER
EBER

La

Fig. 4, Dai Iwakiri and Kenzo Takada (See Page 130 of this volume.)

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